Well first I need to get a PS3, but I am looking forward to

Castlevania: Lords of Shadow
Final Fantasy XIII
Star Craft 2
Star Wars: The Old Republic
Metroid: Other M (didn't realize this was suppose to be coming out this year)

Not sure if anything else is suppose to come out but if what others have posted comes out, then I'll be very happy (although I don't think some will such as Duke Nukem Forever, wishful thinking though).